- Lower blood sugar
- Regulate cholesterol levels
- Increase bio-availability
- Activation of AMPK
- Improve weight loss
Berberine regulates the blood glucose in the body by increasing glycosis which helps the body break down sugar in the blood. This hypoglycemic function, lowering of the blood sugar, occurs through signaling pathways in the liver. It suppresses gluconeogenesis (production of glucose), increase glucose uptake in the muscle, liver, and fat. These actions collectively improve insulin resistance and insulin sensitivity through the activation of AMPK. Berberine was studied to be comparable to that of metformin.
AMPK helps signal when cellular energy is low due to low blood glucose. AMPK helps regulate the body’s blood sugar by breaking down sugar and restoring energy in the tissues. This process also helps improve cholesterol profile. It helps modulate total cholesterol levels by decreasing LDL (bad cholesterol).
This is due to interactions of the liver allowing the body oxidize fatty tissues (activation of AMPK). It also signals LDL receptors to remove LDL from the blood improving overall cholesterol. Berberine itself has very poor bioavailability meaning it is not well absorbed by the body. It has difficulty permeating through the intestinal tract which reduces the efficacy benefits of berberine. To combat this issue and provide substantial benefits we included Sodium Caprate to significantly enhance Berberine absorption.
Our formula was crafted with long hours of research. Basing on medical peer-reviewed journals, we've carefully digested studies and selected the appropriate ingredient to boost the effects of berberine.
Berberine Hydrochloride is an extracted salt form standardized to 97% or higher purity. Berberine can be derived from multiple sources such as Coptis chinensis (Chinese goldthread), Hydrastis canadensis (goldenseal), Berberis vulgaris (barberry), and Berberis aristata (Indian barberry). Berberine has been thoroughly tested for its significant functions in alleviating metabolic syndromes and cardiovascular diseases.
Sodium Caprate (C10) is a medium-chain fatty acid. It helps permeability of berberine through the intestinal tract. Foods that contain medium-chain fatty acids are coconut oil (MCT), cheese, butter, milk and yogurt.
"After coadministration, the area under the plasma concentration-time curve of berberine was increased 28% than that in the absence of sodium caprate. Furthermore, both berberine and coadministration with sodium caprate orally could significantly decrease fasting blood glucose and improve glucose tolerance in diabetic rats (P < 0.05). The hypoglycemic effect of coadministration group was remarkably stronger, and the areas under the glucose curves was decreased 22.5%, compared with berberine treatment group (P < 0.05). "
Lv, Xiao-Yan et al. “Enhancement of sodium caprate on intestine absorption and antidiabetic action of berberine.” AAPS PharmSciTech vol. 11,1 (2010): 372-82. doi:10.1208/s12249-010-9386-z
We wanted to make sure we devise a formula that is not just a simple one ingredient supplement but a formula that improves the function of berberine. After some extensive research, we discovered one common issue with supplements and it's their bioavailability or absorption. We solved this by adding Sodium Caprate, a medium-chain fatty acid that helps enlarge permeable entry in the intestinal tract thus increasing overall benefit of berberine.
Attention: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.